AbstractContinuous monitoring of multiple physiological parameters, such as glucose levels, temperature, and heart rate variability (HRV) is crucial for effective diabetes management and mitigating the risks associated with hypoglycemic events. These events often occur without apparent symptoms, posing a challenge for diabetic patients in managing their condition. Therefore, a non‐invasive wearable device capable of continuously measuring multiple body signals to predict hypoglycemic events would be highly beneficial. In this study, a wearable patch that continuously measures glucose, temperature, and HRV is presented. The device uses a novel power harvesting system to convert radiofrequency (RF) signals with the frequency of 2.45 GHz to direct current (DC) signals to extend the battery life for further continuous monitoring. The patch is small and has a conformal structure that can easily fit onto different body parts. The screen‐printed glucose sensor demonstrates a sensitivity of 10.3 nA cm⁻² µM⁻¹, a limit of detection (LOD) of 8.9 µM, and a limit of quantification (LOQ) of 27 µM. The device employs a photoplethysmography (PPG) module with a peak‐finding algorithm to calculate the HRV values. In vivo experiments demonstrate the validation of the device's proper operation in glucose, HRV, and temperature measurement.