Links
- ORCID
- ORCID
- ORCID
- Crossref | PDF
- [doaj.org] | PDF
- [hdl.handle.net]
- [www.researchgate.net] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
Tools
CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
Journal article published in 2014 by
Matteo Santoni 
,
Sergio Bracarda,
Massimo Nabissi ,
Francesco Massari,
Alessandro Conti ,
Emilio Bria,
Giampaolo Tortora,
Giorgio Santoni,
Stefano Cascinu
,
Sergio Bracarda,
Massimo Nabissi ,
Francesco Massari,
Alessandro Conti ,
Emilio Bria,
Giampaolo Tortora,
Giorgio Santoni,
Stefano Cascinu
Abstract
Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.