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European Centre for Disease Prevention and Control, Eurosurveillance, 13(25), 2020

DOI: 10.2807/1560-7917.es.2020.25.13.2000305

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Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe

Journal article published in 2020 by Paola Stefanelli, Alessandra Lo Presti, Alessandra Lo Presti, Antonella Marchi, Giovanni Faggioni, Stefano Fiore, Antonella Fortunato, Florigio Lista, Eleonora Benedetti, Concetta Fabiani, Maria Rita Gismondo, Anna Anselmo, Andrea Ciammaruconi, Giovanni Rezza, Riccardo De Santis and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Whole genome sequences of SARS-CoV-2 obtained from two patients, a Chinese tourist visiting Rome and an Italian, were compared with sequences from Europe and elsewhere. In a phylogenetic tree, the Italian patient’s sequence clustered with sequences from Germany while the tourist’s sequence clustered with other European sequences. Some additional European sequences in the tree segregated outside the two clusters containing the patients’ sequences. This suggests multiple SARS-CoV-2 introductions in Europe or virus evolution during circulation.