Published in

Wiley, Small, 5(10), p. 871-877, 2013

DOI: 10.1002/smll.201302430

Links

Tools

Export citation

Search in Google Scholar

Intracellular microenvironment responsive polymers: a multiple-stage transport platform for high-performance gene delivery

Journal article published in 2013 by Bingyang Shi ORCID, Hu Zhang, Sheng Dai ORCID, Xin Du ORCID, Jingxiu Bi ORCID, Shi Zhang Qiao
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

A new strategy for promoting endoplasmic gene delivery and nucleus uptake is proposed by developing intracellular microenvironment responsive biocompatible polymers. This delivery system can efficiently load and self-assemble nucleic acids into nano-structured polyplexes at a neutral pH, release smaller imidazole-gene complexes from the polymer backbones at intracellular endosomal pH, transport nucleic acids into nucleus through intracellular environment responsive multiple-stage gene delivery, thus leading to a high cell transfection efficiency. ; Bingyang Shi, Hu Zhang, Sheng Dai, Xin Du, Jingxiu Bi and Shi Zhang Qiao