A mechanically flexible textile antenna-backed sensor node is designed and manufactured, providing accurate personal localization functionality by application of Decawave’s DW1000 Impulse Radio Ultra-Wideband (IR-UWB) Integrated Circuit (IC). All components are mounted on a flexible polyimide foil, which is integrated on the backplane of a wearable cavity-backed slot antenna designed for IR-UWB localization in Channels 2 and 3 of the IEEE 802.15.4-2011 standard (3744 MHz–4742.4 MHz). The textile antenna’s radiation pattern is optimized to mitigate body effects and to minimize absorption by body tissues. Furthermore, its time-domain characteristics are measured to be adequate for localization. By combining the antenna and the bendable Printed Circuit Board (PCB), a mechanically supple sensor system is realized, for which the performance is validated by examining it as a node used in a complete localization system. This shows that six nodes around the body must be deployed to provide system coverage in all directions around the wearer. Even without using sleep mode functionalities, the measurements indicate that the system’s autonomy is 13.3 h on a 5 V 200 mAh battery. Hence, this system acts as a proof of concept for the joining of localization electronics and other sensors with a full-textile antenna into a mechanically flexible sensor system.