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BioMed Central, Biology Direct, 1(9), 2014

DOI: 10.1186/1745-6150-9-22

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Chordopoxvirus protein F12 implicated in enveloped virion morphogenesis is an inactivated DNA polymerase

Journal article published in 2014 by Natalya Yutin, Guilhem Faure, Eugene V. Koonin, Arcady R. Mushegian ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Through the course of their evolution, viruses with large genomes have acquired numerous host genes, most of which perform function in virus reproduction in a manner that is related to their original activities in the cells, but some are exapted for new roles. Here we report the unexpected finding that protein F12, which is conserved among the chordopoxviruses and is implicated in the morphogenesis of enveloped intracellular virions, is a derived DNA polymerase, possibly of bacteriophage origin, in which the polymerase domain and probably the exonuclease domain have been inactivated. Thus, F12 appears to present a rare example of a drastic, exaptive functional change in virus evolution.