Published in
American Physiological Society, American Journal of Physiology - Gastrointestinal and Liver Physiology, 5(320), p. G907-G918, 2021
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Liver injury after small bowel resection is prevented in obesity-resistant 129S1/SvImJ mice
Journal article published in 2021 by
Emily J. Onufer 
,
Yong-Hyun Han,
Cathleen Courtney,
Allie Steinberger,
Maria Tecos,
Stephanie Sutton,
Anne Sescleifer,
Jocelyn Ou,
Rafael Sanguinetti Czepielewski,
Gwendalyn J. Randolph,
Brad W. Warner
,
Yong-Hyun Han,
Cathleen Courtney,
Allie Steinberger,
Maria Tecos,
Stephanie Sutton,
Anne Sescleifer,
Jocelyn Ou,
Rafael Sanguinetti Czepielewski,
Gwendalyn J. Randolph,
Brad W. Warner
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Abstract
Unlike C57BL/6 mice, the 129S1/SvImJ strain is resistant to liver inflammation and injury after small bowel resection. These disparate outcomes are likely due to the accumulation of hepatic free fatty acids as well as increased endotoxin-driven inflammatory pathways through PPARα and TLR4 in C57BL/6 mice with short bowel syndrome.