Published in
Royal Society of Chemistry, Chemical Science, 17(12), p. 6107-6116, 2021
DOI: 10.1039/d0sc06946a
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Molecular mechanism of secreted amyloid-β precursor protein in binding and modulating GABA<sub>B</sub>R1a
Journal article published in 2021 by
Mei Feng,
Yi Song,
Serena H. Chen 
,
Yuanzhao Zhang,
Ruhong Zhou
,
Yuanzhao Zhang,
Ruhong Zhou
This paper is made freely available by the publisher.
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Abstract
A recent phenomenal study discovered that the extension domain of secreted amyloid-β precursor protein (sAPP) can bind to the intrinsically disordered sushi 1 domain of the γ-aminobutyric acid type B receptor subunit 1a (GABABR1a) and modulate its synaptic transmission.