Radiation metrology is crucial in space, for instance in monitoring the conditions on-board space vehicles. The energy released in matter by ionizing radiation is due to the atomic and molecular ionization processes, which have been investigated for several decades from both a theoretical and an experimental point of view. Electronic excitation and ionization cross-section are of particular interest in radiation physics, because of their role in the radiation–matter interaction process. Recently, experimental findings have shown that the interplay with a laser field can strongly modify the electronic interaction probabilities and emission spectra. These phenomena are still not completely understood from a theoretical point of view, and the available empirical data concern a few, simple atomic species. We represent a possible dosimetric effect of the interaction with laser light, inferring from experiments the characteristics of laser-assisted cross-sections. Using a Monte-Carlo calculation for simulating the micro-dosimetric aspects of the irradiation of a simple geometry, we show the need of new experimental data and more detailed theoretical approaches to these phenomena in complex molecular systems.