Published in
Royal Society of Chemistry, Chemical Science, 22(12), p. 7735-7745, 2021
DOI: 10.1039/d0sc06693a
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Stalling chromophore synthesis of the fluorescent protein Venus reveals the molecular basis of the final oxidation step
Journal article published in 2021 by
Husam Sabah Auhim,
Bella L. Grigorenko,
Tessa K. Harris,
Ozan E. Aksakal,
Igor V. Polyakov,
Colin Berry 
,
Gabriel dos Passos Gomes ,
Igor V. Alabugin ,
Pierre J. Rizkallah ,
Alexander V. Nemukhin ,
D. Dafydd Jones
,
Gabriel dos Passos Gomes ,
Igor V. Alabugin ,
Pierre J. Rizkallah ,
Alexander V. Nemukhin ,
D. Dafydd Jones
This paper is made freely available by the publisher.
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Abstract
Fluorescent proteins (FPs) have revolutionised the life sciences, but the chromophore maturation mechanism is still not fully understood. Here we photochemically trap maturation at a crucial stage and structurally characterise the intermediate.