Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 6(65), 2021
DOI: 10.1128/aac.00018-21
Links
Tools
Role of Synonymous Mutations in the Evolution of TEM β-Lactamase Genes
Journal article published in 2021 by
Mohammad Faheem,
Charles J. Zhang 
,
Monica N. Morris ,
Juergen Pleiss ,
Peter Oelschlaeger
,
Monica N. Morris ,
Juergen Pleiss ,
Peter Oelschlaeger
This paper is made freely available by the publisher.
Full text: Download
Data provided by 
Abstract
Nonsynonymous mutations are well documented in TEM β-lactamases. The resulting amino acid changes often alter the conferred phenotype from the broad spectrum (2b) conferred by TEM-1 to extended spectrum (2be), inhibitor resistant (2br), or both extended spectrum and inhibitor resistant (2ber).