Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection
Journal article published in 2021 by
Hernán F. Peñaloza 
,
Tolani F. Olonisakin,
William G. Bain ,
Yanyan Qu,
Rick van der Geest ,
Jill Zupetic,
Mei Hulver,
Zeyu Xiong,
Michael W. Newstead,
Chunbin Zou,
Jonathan K. Alder,
Joel A. Ybe,
Theodore J. Standiford,
Janet S. Lee
,
Tolani F. Olonisakin,
William G. Bain ,
Yanyan Qu,
Rick van der Geest ,
Jill Zupetic,
Mei Hulver,
Zeyu Xiong,
Michael W. Newstead,
Chunbin Zou,
Jonathan K. Alder,
Joel A. Ybe,
Theodore J. Standiford,
Janet S. Lee
This paper is made freely available by the publisher.
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Abstract
Pseudomonas aeruginosa pulmonary infection can lead to exaggerated neutrophilic inflammation and tissue destruction, yet host factors that regulate the neutrophilic response is not fully known. IL-36γ is a proinflammatory cytokine that dramatically increases in bioactivity following N-terminal processing by proteases.