Although epistemic needs motivate the endorsement of system-justifying beliefs, few studies have investigated moderators of this association. Here, we argue that because being the target of discrimination should undermine one’s sense of control, the association between epistemic needs and system-justifying beliefs should be stronger for disadvantaged (vs. advantaged) groups. As hypothesized, analyses of a nation-wide random sample of adults ( N = 14,929) revealed that the negative relationship between openness to experience (i.e., an indicator of low epistemic needs) and multiple system-justifying beliefs (i.e., gender-based system justification, right-wing political preference, and conservative party support) was stronger for women (vs. men), and that these moderated associations were mediated by perceptions of gender discrimination. Our results suggest that women may sometimes endorse beliefs that conflict with their self and group interests in order to satisfy their epistemic needs.