Objective: To determine the relationship between psychosocial risk factors and professional satisfaction of workers working in oncology and palliative care units in a region of Chile. Material and Method: Non experimental, cross-sectional, correlational study with quantitative approach. In the last semester of 2016, the census of health workers was carried out, using an instrument composed of three parts for data collection: a) bio-sociodemographic history, b) SUSESO-ISTAS 21 questionnaire for psychosocial risks, and c) for work satisfaction. International bioethical principles were respected throughout the research. Results: There is a relationship with statistical significance (p≤0,05) between psychosocial risks and job satisfaction at work, the dimension of psychosocial risk with higher risk is psychological demand (x:11,24; DP: 3,06) and dual presence (x: 3,23; DP: 1,90) and the factor in which less satisfaction is perceived is the physical work environment (x: 4,32 DP: 1,77). Conclusion: With the results obtained, it can be affirmed that the workers who work in oncologic units and perceive greater psychosocial risk at work present less satisfaction at work, which can impact on the quality of assistance.