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American Society for Microbiology, mBio, 2(12), 2021

DOI: 10.1128/mbio.00226-21

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In VivoAntigen Expression Regulates CD4 T Cell Differentiation and Vaccine Efficacy against Mycobacterium tuberculosis Infection

Journal article published in 2021 by Helena Strand Clemmensen ORCID, Jean-Yves Dube, Fiona McIntosh, Ida Rosenkrands, Gregers Jungersen, Claus Aagaard ORCID, Peter Andersen, Marcel A. Behr ORCID, Rasmus Mortensen ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Tuberculosis, caused by Mtb, constitutes a global health crisis of massive proportions, and the impact of the current coronavirus disease 2019 (COVID-19) pandemic is expected to cause a rise in tuberculosis-related deaths. Improved vaccines are therefore needed more than ever, but a lack of knowledge on protective immunity hampers their development.