Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(65), 2021
DOI: 10.1128/aac.01892-20
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Toward Chemical Validation of Leishmania infantum Ribose 5-Phosphate Isomerase as a Drug Target
Journal article published in 2021 by
Emily A. Dickie,
Céline Ronin,
Mónica Sá,
Fabrice Ciesielski,
Nathalie Trouche,
Joana Tavares 
,
Nuno Santarem,
Louise L. Major ,
Iain K. Pemberton,
Jane MacDougall,
Terry K. Smith ,
Anabela Cordeiro-Da-Silva,
Paola Ciapetti
,
Nuno Santarem,
Louise L. Major ,
Iain K. Pemberton,
Jane MacDougall,
Terry K. Smith ,
Anabela Cordeiro-Da-Silva,
Paola Ciapetti
This paper is made freely available by the publisher.
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Abstract
Neglected tropical diseases caused by kinetoplastid parasites ( Trypanosoma brucei , Trypanosoma cruzi , and Leishmania spp.) place a significant health and economic burden on developing nations worldwide. Current therapies are largely outdated, inadequate, and face mounting drug resistance from the causative parasites.