Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(65), 2021
DOI: 10.1128/aac.02502-20
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Melting the eis : Nondetection of Kanamycin Resistance Markers by Routine Diagnostic Tests and Identification of New eis Promoter Variants
Journal article published in 2021 by
Serej D. Ley 
,
Samantha Pillay,
Elizabeth M. Streicher ,
Yuri F. van der Heijden,
Frederik Sirgel,
Brigitta Derendinger,
Marianna de Kock,
Sébastien Gagneux ,
Robin M. Warren,
Grant Theron,
Margaretha de Vos
,
Samantha Pillay,
Elizabeth M. Streicher ,
Yuri F. van der Heijden,
Frederik Sirgel,
Brigitta Derendinger,
Marianna de Kock,
Sébastien Gagneux ,
Robin M. Warren,
Grant Theron,
Margaretha de Vos
This paper is made freely available by the publisher.
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Abstract
Eis promoter mutations can confer reduced Mycobacterium tuberculosis kanamycin susceptibility. GenoType MTBDR sl, a widely used assay evaluating this region, wrongly classified 17/410 isolates as eis promoter wild type.