Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 7(65), 2021
DOI: 10.1128/aac.00097-21
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Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral Replication
,
Carlota Fernandez-Antunez,
Andrea Galli ,
Alexander Underwood,
Long V. Pham,
Line A. Ryberg,
Shan Feng,
Martin S. Pedersen,
Lotte S. Mikkelsen,
Sandrine Belouzard,
Jean Dubuisson ,
Christina Sølund,
Nina Weis,
Judith M. Gottwein ,
Ulrik Fahnøe
and other authors.
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Abstract
Efforts to mitigate the coronavirus disease 2019 (COVID-19) pandemic include the screening of existing antiviral molecules that could be repurposed to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Although SARS-CoV-2 replicates and propagates efficiently in African green monkey kidney (Vero) cells, antivirals such as nucleos(t)ide analogs (nuc’s) often show decreased activity in these cells due to inefficient metabolization.