American Physiological Society, American Journal of Physiology - Renal Physiology, 6(320), p. F1106-F1122, 2021
DOI: 10.1152/ajprenal.00556.2020
Full text: Unavailable
Ksp-cadherin (cadherin-16) is an atypical member of the cadherin superfamily of cell adhesion molecules that is ubiquitously expressed on the basolateral membrane of epithelial cells lining the nephron and the collecting system. Using knockout mice, we found that Ksp-cadherin is in fact not required for kidney development despite its high and specific expression along the nephron. However, its absence leads to a developmental delay in maximal urinary concentrating ability.