Reliable and resilient constructions are basic for ensuring the safety of various structures. The superalloys are used as constructive materials due to their superb mechanical properties and endurance. However, even these materials can have certain areas where the stress concentration is higher than expected, such as drilling holes, which are common in various structures that need additional enhancement. Surface laser modifications of the areas surrounding the holes drilled in Nimonic 263 sheets are done by pulsed picosecond and nanosecond Nd:YAG laser irradiations with pulse durations of 170 ps and ≤8 ns, respectively. Following the laser surface treatment, the effectiveness of the enhancement was analyzed by the microhardness test and the deformation test. The results show that the deformation and stress values are decreased by 25−40 percent, showing the improvement in the resilience to deformation. The Vickers microhardness test results indicate an improvement in the Nimonic 263 microhardness. The dimensions of the microcracks are higher for the untreated material in comparison to the laser-treated material.