In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
Journal article published in 2021 by
Melina Vallbracht 
,
Henriette Lötzsch,
Barbara G. Klupp,
Walter Fuchs,
Benjamin Vollmer ,
Kay Grünewald,
Marija Backovic,
Felix A. Rey,
Thomas C. Mettenleiter
,
Henriette Lötzsch,
Barbara G. Klupp,
Walter Fuchs,
Benjamin Vollmer ,
Kay Grünewald,
Marija Backovic,
Felix A. Rey,
Thomas C. Mettenleiter
This paper is made freely available by the publisher.
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Abstract
The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.