Background: The purpose of this study is to compare training load (TL) preceding a home versus away match in a top-class elite European team during the 2015–2016 season. Methods: Twenty elite outfield soccer players with a mean ± SD age, height and body mass of 25.9 ± 4.6 years, 183.1 ± 6.6 cm and 78.6 ± 6.6 kg, respectively, participated in this study. Total distance covered, high-speed running distance (HSRD), average speed (AvS), rating of perceived exertion (RPE) multiplied by training duration (s-RPE) and Hooper index (HI) were collected. Data from 24 weeks were analyzed through match-day minus/plus approach (MD-5, -4, -3, -2, -1, MD + 1). Results: All external TL variables indicated a decrease from MD-5 until MD-1 and then an increase to MD + 1 (p < 0.01). HI decreased from MD-5 to MD-1, but s-RPE increased until MD-3 and then decreased until MD + 1. When comparing TL data that preceded home matches versus away matches, for MD-5, HSRD and muscle soreness exhibited higher values when away match neared (p < 0.05). For MD-4 and MD-3, total distance, HSRD and AvS exhibited higher values closer to an away match than a home match (p < 0.05). For MD-1, total distances covered were higher closer to a home match than an away match (p < 0.01). For MD + 1, all HI items and AvS were higher when an away match was played (p < 0.05). Conclusions: This study confirms and provides evidence regarding the influence on internal and external TL data preceding home and away matches from a team that played in European competitions.