Published in
American Society for Microbiology, Journal of Virology, 15(95), 2021
DOI: 10.1128/jvi.00766-21
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Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication
Journal article published in 2021 by
Lynden S. Voth,
Joseph J. O’Connor,
Catherine M. Kerr,
Ethan Doerger,
Nancy Schwarting,
Parker Sperstad,
David K. Johnson,
Anthony R. Fehr 
This paper is made freely available by the publisher.
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Abstract
In the wake of the COVID-19 epidemic, there has been a surge to better understand how CoVs replicate and to identify potential therapeutic targets that could mitigate disease caused by SARS-CoV-2 and other prominent CoVs. The highly conserved macrodomain, also termed Mac1, is a small domain within nonstructural protein 3.