ABSTRACTCrustal earthquakes in low-strain-rate regions are rare in the human life span but can generate disastrous consequences when they occur. Such was the case in the Canterbury earthquake sequence that began in 2010 and eventually led to almost 200 fatalities. Our study explores this earthquake sequence’s origins by producing an enhanced earthquake catalog in the Canterbury Plains and Otago, South Island, New Zealand. We investigate seismicity rate changes from 2005 to before the 2010 Mw 7.2 Darfield earthquake. During this time, major subduction-zone earthquakes, such as the 2009 Mw 7.8 Dusky Sound earthquake, created measurable coseismic and postseismic strain in the region. We use template matching to expand the catalog of earthquakes in the region, and use a support vector machine classifier to remove false positives and poor detections. We then compare the newly obtained seismicity rates with the coseismic and postseismic crustal strain fields, and find that seismicity rate and crustal strain are positively correlated in the low-stress, low-seismicity region of the northern Canterbury Plains. In contrast, near fast-moving plate-boundary faults, the seismicity rate changes rise without much change in the strain rate. Our analysis reveals a substantial seismicity rate decrease in the western rupture area of the Darfield earthquake, which we infer to be an effect of coseismic and postseismic deformation caused by the Dusky Sound earthquake. We show in low-strain-rate regions, stress perturbation of a few kPas creates substantial seismicity rate change. However, the implication that such seismic quiescence is responsible for the nucleation of the Darfield earthquake requires further studies.