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OpenAlex, 2021

DOI: 10.60692/11jke-a2003

OpenAlex, 2021

DOI: 10.60692/vbkbz-62811

Oxford University Press, Clinical Infectious Diseases, Supplement_3(73), p. S229-S237, 2021

DOI: 10.1093/cid/ciab528

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Global Respiratory Syncytial Virus–Related Infant Community Deaths

Journal article published in 2021 by Ángela Gentile, Şule Gökçe, Yvette N. Löwensteyn, Fernanda de-Paris, Patricia Gomes de Matos Bezerra, Natalie I. Mazur, Zheng de Xie, Yvette N. Löwensteyn, Eliana Zemanate, Joukje E. Willemsen, Yoke FunChan, Christopher J. Gill, Natalie I. Mazur, Joukje Willemsen, Lawrence M. Mwananyanda and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.