Objective - This study aims to examine the contribution of personality, stress of driver and driver behavior as a mediator on road accident among bus driver in Indonesia. The study adopts a survey method to elicit responses from a sample of 400 bus driver who were selected as a Respondent type. The brief purpose of the paper and illustrate the direction that is taken, whether it is empirical or theoretical testing in analyzing the research subject. Methodology/Technique - The Data collecting using the Big Five Personality questionnaires, Driver Stress Inventory, Driver Behavior questionnaires and Road Accident Inventory. The data collected were analysis confirmatory factor analysis and Structural Equation Model (SEM) Findings - The SEM results show that the model hypothesis predictor index of road accidents have a good match but personality factors do not have affect directly on road accident and the stress of driver and driver behavior have a significant effect on Road accident; therefore the model needs to be re-specified.All of the predictors have influenced for 4% of variance on road accidents. Two predictor variables were accounted for 24% of variance on the behavior of drivers. Stress drivers directly affecting road accidents by (β = .13), and driver behavior (β = .07) .Two predictor variables on the driver behavior also reveals that the personality basis directly affects the behavior of the driver (β = .18), followed by stress of the driver have a direct influence on the behavior of drivers (β = .38). The factor of driver behavior error and lapses have strong effect to road accident Novelty - The implication this study show that there is a need for an intervention program in order to reduce the prevalence of accident involvement due to personality factors. The latter should be focused on managing driving behavior. Type of Paper - Emperical Keywords: Driver Stress, Driver Behavior, Road, Accident, Indonesia.