Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.

Das, Swapan Kumar; Chu, Winston S.; Hale, Terri C.; Wang, Xiaoqin; Craig, Rebekah L.; Wang, Hua; Shuldiner, Alan R.; Froguel, Philippe; Deloukas, Panos; McCarthy, Mark I.; Zeggini, Eleftheria; Hasstedt, Sandra J.; Elbein, Steven C.

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Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.

Journal article published in 2006 by Swapan Kumar Das, Winston S. Chu, Terri C. Hale, Xiaoqin Wang, Rebekah L. Craig, Hua Wang, Alan R. Shuldiner, Philippe Froguel, Panos Deloukas

, Mark I. McCarthy, Eleftheria Zeggini

, Sandra J. Hasstedt, Steven C. Elbein

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Abstract

Linkage of type 2 diabetes to chromosome 1q21-q23 is well replicated across populations. In an initial 50-kb marker map (580 markers) across the linked region, one of the two strongest associations observed in Utah Caucasians was at marker rs1503814 (P