Published in
Royal Society of Chemistry, Nanoscale Advances, 14(3), p. 4166-4185, 2021
DOI: 10.1039/d1na00133g
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Dynamic interactions and intracellular fate of label-free, thin graphene oxide sheets within mammalian cells: role of lateral sheet size
Journal article published in 2021 by
Yingxian Chen,
Jack Rivers-Auty 
,
Livia Elena Crică,
Crică Le,
Katie Barr,
Vinicio Rosano,
Arranz Ae,
Adrián Esteban Arranz,
Thomas Loret,
David Spiller,
Cyrill Bussy ,
Kostas Kostarelos ,
Sandra Vranic
,
Livia Elena Crică,
Crică Le,
Katie Barr,
Vinicio Rosano,
Arranz Ae,
Adrián Esteban Arranz,
Thomas Loret,
David Spiller,
Cyrill Bussy ,
Kostas Kostarelos ,
Sandra Vranic
This paper is made freely available by the publisher.
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Abstract
This study reveals the dependence of GO uptake mechanism on its lateral dimensions. The main uptake mechanism of s-GO shifts from macropinocytosis (4 h) to clathrin-dependent endocytosis (24 h), mediated by upregulation of mTORC1/2 pathway.