ABSTRACT Understanding the processes that may be at the origin of major earthquakes in subduction zones is highly challenging, especially in the case of slowly converging areas such as the Lesser Antilles subduction zone. Our study reveals a recorded increase in seismicity rate and cumulative seismic moment over the last two decades offshore Martinique island and, particularly, in the presumed rupture area of the major historical 1839 earthquake. This sustained seismicity is shared between extensive intermediate depth activity since the 2007 Mw 7.4 earthquake that occurred about 20 km north of Martinique and a compressive seismic cluster located in the seismogenic zone of the subduction zone. We also observe a downward migration of the seismicity along the plate interface up to a 60–65 km depth and a recorded increase in the magnitudes of the earthquakes. All these observations may indicate ongoing changes along the plate boundary interface near the area of the historical major rupture of 1839, although more detailed statistical studies and additional data are necessary to confirm this trend.