American Society for Microbiology, Journal of Virology, 20(95), 2021
DOI: 10.1128/jvi.00906-21
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Human infections with avian influenza A viruses upon exposure to infected birds are frequently reported and have received attention as a potential pandemic threat. Cleavage of the envelope glycoprotein hemagglutinin (HA) by host proteases is a prerequisite for membrane fusion and essential for virus infectivity.