Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 10(65), 2021
DOI: 10.1128/aac.01060-21
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Of Rats and Men: a Translational Model To Understand Vancomycin Pharmacokinetic/Toxicodynamic Relationships
Journal article published in 2021 by
Marc H. Scheetz 
,
Gwendolyn M. Pais ,
Thomas P. Lodise ,
Steven Y. C. Tong ,
Joshua S. Davis,
J. Nicholas O’Donnell ,
Jiajun Liu,
Michael Neely,
Walter C. Prozialeck,
Peter C. Lamar,
Nathaniel J. Rhodes ,
Thomas Holland,
Sean N. Avedissian
,
Gwendolyn M. Pais ,
Thomas P. Lodise ,
Steven Y. C. Tong ,
Joshua S. Davis,
J. Nicholas O’Donnell ,
Jiajun Liu,
Michael Neely,
Walter C. Prozialeck,
Peter C. Lamar,
Nathaniel J. Rhodes ,
Thomas Holland,
Sean N. Avedissian
This paper is made freely available by the publisher.
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Abstract
Vancomycin area under the concentration curve (AUC) is known to predict vancomycin-induced acute kidney injury (AKI). Data were analyzed from a rat model ( n = 48) and two prospective clinical studies (PROVIDE [ n = 263] and CAMERA2 [ n = 291]).