Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(65), 2021
DOI: 10.1128/aac.02399-20
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Relationship between Plasma and Intracellular Concentrations of Bedaquiline and Its M2 Metabolite in South African Patients with Rifampin-Resistant Tuberculosis
Journal article published in 2021 by
Precious Ngwalero,
James C. M. Brust,
Stijn W. van Beek,
Sean Wasserman 
,
Gary Maartens ,
Graeme Meintjes,
Anton Joubert,
Jennifer Norman,
Sandra Castel,
Neel R. Gandhi ,
Paolo Denti ,
Helen McIlleron ,
Elin M. Svensson,
Lubbe Wiesner
,
Gary Maartens ,
Graeme Meintjes,
Anton Joubert,
Jennifer Norman,
Sandra Castel,
Neel R. Gandhi ,
Paolo Denti ,
Helen McIlleron ,
Elin M. Svensson,
Lubbe Wiesner
This paper is made freely available by the publisher.
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Abstract
Bedaquiline is recommended for the treatment of all patients with rifampin-resistant tuberculosis (RR-TB). Bedaquiline accumulates within cells, but its intracellular pharmacokinetics have not been characterized, which may have implications for dose optimization.