Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells
Journal article published in 2021 by
Rocio Garcia-Rubio,
Cristina Jimenez-Ortigosa,
Lucius DeGregorio,
Christopher Quinteros,
Erika Shor 
,
David S. Perlin
,
David S. Perlin
This paper is made freely available by the publisher.
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Abstract
Echinocandin drugs are a first-line therapy to treat invasive candidiasis, which is a major source of morbidity and mortality worldwide. The opportunistic fungal pathogen Candida glabrata is a prominent bloodstream fungal pathogen, and it is notable for rapidly developing echinocandin-resistant strains associated with clinical failure.