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Sociedade Brasileira de Química, SBQ, Journal of the Brazilian Chemical Society, 3a(16), p. 495-499, 2005

DOI: 10.1590/s0103-50532005000300026

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A Concise Total Synthesis of (R)-Fluoxetine, a Potent and Selective Serotonin Reuptake Inhibitor

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

(R)-Fluoxetine, potent and selective serotonin reuptake inhibitor, has been synthesized in six steps, 50% overall yield and 99% ee from benzaldehyde via catalytic asymmetric allylation with Maruoka´s catalyst.