National Academy of Sciences, Proceedings of the National Academy of Sciences, 33(118), 2021
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Significance There is a lack of global observational data to monitor the application of nonpharmaceutical interventions (NPI) and evaluate the effect of NPIs for pandemic management in different territories. We find that economic activity reduction inferred from NO 2 is a driver of case deceleration in most of the territories. The effect, however, is not linear but dampens over time, and further reductions are only associated with weaker deceleration. Over the winter of 2020/2021, nearly 1 million daily COVID-19 cases could have been avoided by optimizing the timing and strength of activity reduction in different regions relative to a scenario based on the real distribution.