Published in
American Society for Microbiology, Journal of Virology, 20(95), 2021
DOI: 10.1128/jvi.00592-21
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A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters
Journal article published in 2021 by
Mijia Lu,
Yuexiu Zhang,
Piyush Dravid,
Anzhong Li,
Cong Zeng 
,
Mahesh Kc,
Sheetal Trivedi,
Himanshu Sharma,
Supranee Chaiwatpongsakorn,
Ashley Zani,
Adam Kenney,
Chuanxi Cai,
Chengjin Ye,
Xueya Liang,
Jianming Qiu
and other authors.
,
Mahesh Kc,
Sheetal Trivedi,
Himanshu Sharma,
Supranee Chaiwatpongsakorn,
Ashley Zani,
Adam Kenney,
Chuanxi Cai,
Chengjin Ye,
Xueya Liang,
Jianming Qiu
and other authors.
This paper is made freely available by the publisher.
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Abstract
Viral mRNA cap methyltransferase (MTase) is essential for mRNA stability, protein translation, and innate immune evasion. Thus, viral mRNA cap MTase activity is a novel target for development of live attenuated or live vectored vaccine candidates.