Published in
American Association for the Advancement of Science, Science Translational Medicine, 607(13), 2021
DOI: 10.1126/scitranslmed.abd5750
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ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156
Journal article published in 2021 by
Balakrishna Koneru 
,
Ahsan Farooqi ,
Thinh H. Nguyen ,
Wan Hsi Chen ,
Ashly Hindle,
Cody Eslinger ,
Monish Ram Makena ,
Trevor A. Burrow,
Joanne Wilson ,
Aaron Smith ,
Venkatesh Pilla Reddy ,
Elaine Cadogan ,
Stephen T. Durant ,
C. Patrick Reynolds
,
Ahsan Farooqi ,
Thinh H. Nguyen ,
Wan Hsi Chen ,
Ashly Hindle,
Cody Eslinger ,
Monish Ram Makena ,
Trevor A. Burrow,
Joanne Wilson ,
Aaron Smith ,
Venkatesh Pilla Reddy ,
Elaine Cadogan ,
Stephen T. Durant ,
C. Patrick Reynolds
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Abstract
ATM activation at telomeres confers chemoresistance in ALT neuroblastoma and is reversible in preclinical models by ATM knockdown or inhibition.