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National Academy of Sciences, Proceedings of the National Academy of Sciences, 34(118), 2021

DOI: 10.1073/pnas.2104420118

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Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

Journal article published in 2021 by Catarina F. Almeida, Dylan G. M. Smith, Tan-Yun Cheng, Chris M. Harpur ORCID, Elena Batleska, Catriona V. Nguyen-Robertson, Tram Nguyen, Tamara Thelemann, Scott J. J. Reddiex ORCID, Shihan Li, Sidonia B. G. Eckle ORCID, Ildiko Van Rhijn, Jamie Rossjohn ORCID, Adam P. Uldrich ORCID, D. Branch Moody and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Significance Whereas T cells are known to recognize peptides, vitamin B metabolites, or lipid antigens, we identify several nonlipidic small molecules classified as pentamethylbenzofuransulfonates (PBFs) that activate a population of CD1d-restricted natural killer T (NKT) cells. This represents a breakthrough in the field of NKT cell biology. This study also reveals a previously unknown population of PBF-reactive NKT cells in healthy individuals with stereotyped receptors that paves the way for future studies of the role of these cells in immunity, including sulfa drug hypersensitivity.