The skin is the largest organ of the human body and its integrity and ability to regenerate are essential for the maintenance of physiological homeostasis. Any damage to this barrier requires activation of complex cascades which lead to tissue healing and restoration of its proper function. A range of factors, including psychological factors, stress, infections, and underlying disorders such as diabetes or peripheral vascular disease, may interfere with this process and consequently lead to impaired, excessive, and prolonged healing. This article will focus on the impact of stress on the wound healing process, its underlying biological mechanisms, and the influence of psychological factors. Possible ways of minimizing its negative effects on the course of wound treatment will be discussed.