We report the discovery of a new species of Enyalioides from the premontane forest of the Río Huallaga basin in central Peru. The most similar and phylogenetically related species are E. binzayedi and E. rudolfarndti. However, the new species differs from E. binzayedi (state of character in parentheses) by having dorsal scales strongly keeled on paravertebral region and feebly keeled or smooth elsewhere (prominent medial keel on each dorsal scale), more dorsals in transverse row between dorsolateral crests at midbody 26–39, x̄ = 30.44 (22–31, x̄ = 27.57), and a conspicuous posteromedial black patch in the gular region of males (absent). Contrarily, adult males of the new species and E. rudolfarndti are readily distinguished by having a conspicuous posteromedial black patch in the gular region, absent in E. rudolfarndti, and by lacking a conspicuous orange blotch (faint if present) on the antehumeral region, as in E. rudolfarndti. We also present an updated molecular phylogenetic tree of hoplocercines, which strongly supports both referral of the newly discovered species to Enyalioides and its status as distinct from those recognized previously.