Published in
American Society for Microbiology, Microbiology Spectrum, 2(9), 2021
DOI: 10.1128/spectrum.00318-21
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Clarithromycin Inhibits Pneumolysin Production via Downregulation of ply Gene Transcription despite Autolysis Activation
Journal article published in 2021 by
Hisanori Domon 
,
Toshihito Isono,
Takumi Hiyoshi,
Hikaru Tamura,
Karin Sasagawa,
Tomoki Maekawa,
Satoru Hirayama ,
Katsunori Yanagihara,
Yutaka Terao
,
Toshihito Isono,
Takumi Hiyoshi,
Hikaru Tamura,
Karin Sasagawa,
Tomoki Maekawa,
Satoru Hirayama ,
Katsunori Yanagihara,
Yutaka Terao
This paper is made freely available by the publisher.
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Abstract
Pneumolysin is a potent intracellular toxin possessing multiple functions that augment pneumococcal virulence. For over 10 years, sub-MICs of macrolides, including clarithromycin, have been recognized to decrease pneumolysin production and release from pneumococcal cells.