Published in
Wiley Open Access, Clinical Case Reports, 4(9), p. 2249-2253, 2021
DOI: 10.1002/ccr3.4002
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Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood‐brain barrier be a disease “sanctuary” during venetoclax treatment?
Journal article published in 2021 by
Maria Dimou 
,
Aikaterini Bitsani,
Maria Roumelioti,
Aglaia Dimitrakopoulou,
Theodore Iliakis,
Vasileios Pardalis,
Ioannis Grafakos,
Sotiria Kalyva,
Athanasios Markopoulos,
Marie‐Christine Kyrtsonis,
Panayiotis Panayiotidis
,
Aikaterini Bitsani,
Maria Roumelioti,
Aglaia Dimitrakopoulou,
Theodore Iliakis,
Vasileios Pardalis,
Ioannis Grafakos,
Sotiria Kalyva,
Athanasios Markopoulos,
Marie‐Christine Kyrtsonis,
Panayiotis Panayiotidis
This paper is made freely available by the publisher.
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Abstract
AbstractOur unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood‐brain barrier and at what extend, especially in reduced doses given for drug‐drug interactions.