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MDPI, Pharmaceuticals, 3(14), p. 237, 2021

DOI: 10.3390/ph14030237

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The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge Management: Achievements and Perspectives

Journal article published in 2021 by François Pognan, Thomas Steger-Hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu ORCID, Katharine Briggs, Giulia Callegaro ORCID, Salvador Capella-Gutierrez ORCID, Emilio Centeno, Javier Corvi ORCID, Philip Drew ORCID, William C. Drewe, José M. Fernández ORCID, Laura I. Furlong, Emre Guney ORCID and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.