Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(65), 2021
DOI: 10.1128/aac.01381-21
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Linezolid Population Pharmacokinetics in South African Adults with Drug-Resistant Tuberculosis
Journal article published in 2021 by
Mahmoud Tareq Abdelwahab 
,
Sean Wasserman ,
James C. M. Brust,
Keertan Dheda ,
Lubbe Wiesner ,
Neel R. Gandhi ,
Robin M. Warren,
Frederick A. Sirgel,
Graeme Meintjes,
Gary Maartens ,
Paolo Denti
,
Sean Wasserman ,
James C. M. Brust,
Keertan Dheda ,
Lubbe Wiesner ,
Neel R. Gandhi ,
Robin M. Warren,
Frederick A. Sirgel,
Graeme Meintjes,
Gary Maartens ,
Paolo Denti
This paper is made freely available by the publisher.
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Abstract
Linezolid is widely used for drug-resistant tuberculosis (DR-TB) but has a narrow therapeutic index. To inform dose optimization, we aimed to characterize the population pharmacokinetics of linezolid in South African participants with DR-TB and explore the effect of covariates, including HIV coinfection, on drug exposure.