Published in
American Society for Microbiology, Journal of Virology, 23(95), 2021
DOI: 10.1128/jvi.01358-21
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CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats
Journal article published in 2021 by
Michele Lai 
,
Eyal Maori,
Paola Quaranta,
Giulia Matteoli,
Fabrizio Maggi,
Marco Sgarbanti ,
Stefania Crucitta,
Simone Pacini,
Ombretta Turriziani ,
Guido Antonelli ,
Jonathan L. Heeney,
Giulia Freer,
Mauro Pistello
,
Eyal Maori,
Paola Quaranta,
Giulia Matteoli,
Fabrizio Maggi,
Marco Sgarbanti ,
Stefania Crucitta,
Simone Pacini,
Ombretta Turriziani ,
Guido Antonelli ,
Jonathan L. Heeney,
Giulia Freer,
Mauro Pistello
This paper is made freely available by the publisher.
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Abstract
The excision of HIV-1 provirus from the host cell genome has proven feasiblein vitroand, to some extent,in vivo. Among the different approaches, CRISPR/Cas9 is the most promising tool for gene editing.