Published in
American Society for Microbiology, Journal of Virology, 23(95), 2021
DOI: 10.1128/jvi.01249-21
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Structural Study of Aavrh.10 Receptor and Antibody Interactions
Journal article published in 2021 by
Mario Mietzsch,
Jennifer C. Yu,
Jane Hsi,
Paul Chipman,
Felix Broecker,
Zhang Fuming,
Robert J. Linhardt,
Peter H. Seeberger,
Regine Heilbronn 
,
Robert McKenna ,
Mavis Agbandje-Mckenna
,
Robert McKenna ,
Mavis Agbandje-Mckenna
This paper is made freely available by the publisher.
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Abstract
Gene therapy vectors based on adeno-associated virus rhesus isolate 10 (AAVrh.10) have been used in several clinical trials to treat monogenetic diseases. However, compared to other AAV serotypes little is known about receptor binding and antigenicity of the AAVrh.10 capsid.