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Oxford University Press, Japanese Journal of Clinical Oncology, 1(52), p. 47-52, 2021

DOI: 10.1093/jjco/hyab164

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Fracture risk following stereotactic body radiotherapy for long bone metastases

Journal article published in 2021 by Kei Ito ORCID, Yujiro Nakajima ORCID, Hiroaki Ogawa, Kentaro Taguchi
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background Stereotactic body radiotherapy is a new treatment modality for long bone metastasis and has not been discussed in literature. We aimed to clarify stereotactic body radiotherapy outcomes for long bone metastases. Methods Data of patients receiving stereotactic body radiotherapy for long bone metastases (July 2016–November 2020) were retrospectively reviewed. The prescribed dose was 30 or 35 Gy in five fractions. The endpoints were local failure and adverse effects. Local failure was defined as radiological tumor growth within the irradiation field. Adverse effects were evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events, version 5. Results Nineteen osseous lesions in 17 patients were assessed. The target lesions included 13 femoral, 4 humeral and 2 radial lesions. The median follow-up duration was 14 (range, 3–62) months. The 12- and 18-month local failure rates were 0 and 11%, respectively. Following 2 and 46 months of stereotactic body radiotherapy, two lesions (11%) resulted in painful femoral fractures (grade 3). Both patients underwent bipolar hip arthroplasty and could walk normally after surgery. In the late phase, one patient developed radiculopathy (almost complete paralysis of grasp) and another developed grade 2 limb edema. Other grade 2 or more severe acute and late toxicities were not observed during the follow-up period. Conclusions Stereotactic body radiotherapy for long bone metastases achieved excellent local control and caused two femoral fractures. We argue that stereotactic body radiotherapy for curative intent should not be contraindicated in long bone oligometastasis because fractures do not directly contribute to life expectancy.