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Springer Verlag, Advances in Experimental Medicine and Biology, p. 281-288

DOI: 10.1007/978-1-4614-7411-1_38

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Application of MOBILE (Mapping of Oxygen By Imaging Lipids relaxation Enhancement) to Study Variations in Tumor Oxygenation

Journal article published in 2013 by Bénédicte F. Jordan, Julie Magat, Florence Colliez, Elif Ozel, Anne-Catherine Fruytier, Valérie Marchand, Lionel Mignion ORCID, Bernard Gallez
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The aim of the study was to sensitively monitor changes in tumor oxygen using the MOBILE (mapping of oxygen by imaging lipids relaxation enhancement) technique. This method was applied in mammary tumor mouse models on an 11.7T Bruker MRI system. MOBILE was compared with functional imaging R2*, R1 of water and with pO2 measurements (using EPR oximetry and O2-dependent fluorescence quenching measurements). MOBILE was shown to be capable to monitor changes in oxygenation in tumor tissues.