Published in
American Association for the Advancement of Science, Science Translational Medicine, 613(13), 2021
DOI: 10.1126/scitranslmed.abe7104
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CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington’s disease
Journal article published in 2021 by
Sara Picó 
,
Alberto Parras ,
María Santos-Galindo ,
Julia Pose-Utrilla ,
Margarita Castro ,
Enrique Fraga ,
Ivó H. Hernández,
Ainara Elorza ,
Héctor Anta ,
Nan Wang,
Laura Martí-Sánchez ,
Eulàlia Belloc ,
Paula Garcia-Esparcia ,
Juan J. Garrido ,
Isidro Ferrer
and other authors.
,
Alberto Parras ,
María Santos-Galindo ,
Julia Pose-Utrilla ,
Margarita Castro ,
Enrique Fraga ,
Ivó H. Hernández,
Ainara Elorza ,
Héctor Anta ,
Nan Wang,
Laura Martí-Sánchez ,
Eulàlia Belloc ,
Paula Garcia-Esparcia ,
Juan J. Garrido ,
Isidro Ferrer
and other authors.
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Abstract
Altered CPEBs and mRNA polyadenylation lead to thiamine deficiency in the brains of patients and mice with Huntington’s disease.