Objectives: This study aimed to evaluate the frictional resistance produced by active and passive self-ligating brackets on stainless steel archwires in the absence or presence of elastomeric chains under or over the wire. Materials and Methods: Four types of self-ligating brackets were used: Two active and two passive. For each commercial brand, five brackets were bonded to an acrylic plate and the frictional resistance was evaluated with 0.018” and 0.019” × 0.025” stainless steel wires in three situations: Without elastomeric chain, with elastomeric chain placed under and over the wire. Results: The bracket type, cross-section of the wire, and type of ligation had significant interactions with each other; the frictional resistance was significantly lower with the use of passive self-ligated brackets, while no difference was found when a 0.018” wire was tested. Moreover, the frictional resistance in the absence of an elastomeric chain, or when the chain was under the wire, was significantly lower in comparison with the values obtained when the chain was placed on the wire. Conclusion: Frictional resistance of passive and active self-ligated brackets is influenced by the ligation methods and the cross-sectioning of archwires.